TRPV4 and diabetes mellitus: In view that Trpv4−/− and wild-type mice treated with a TRPV4 antagonist did not develop insulin resistance under high-fat diet93 and that this diet associates with retinal dysfunction94, our findings implicate that (i) TRPV4 blockage disables one or more signaling pathways that participate in diabetes-induced alterations of the retinal neurovascular complex5,66 and/or that (ii) TRPV4 activity is excessive in the diabetic retina44.