TFG and hereditary motor and sensory neuropathy, Okinawa type: Given that the heterozygous TFG mutation is sufficient to cause HMSN-P and that TFG-positive cytoplasmic inclusions were observed in the motor neurons of one patient6, glucose intolerance in HMSN-P patients might be attributable to the cytotoxicity of abnormal TFG rather than to lack of TFG function as shown in our study.