In this study, we identified three interactions involving NLRP3 SNPs associated with outcomes of unrelated BMT: an interaction between recipient NLRP3 and total HLA MMs with grade 2–4 AGVHD; an interaction between donor NLRP3 and HLA-C MM with ECGVHD; and an interaction between recipient NLRP3 and donor CMV serostatus with OS. This evidence concerns the gene NLRP3 and Miyoshi myopathy.