Interestingly, etanercept could restore ERG expression and reduce SMAD3 activity in the in vivo model of CCL4-induced liver fibrosis in wild-type mice, but was ineffective in ErgcEC-het mice, suggesting that anti-TNF therapies exert a beneficial effect by restoring endothelial homoeostasis through the ERG pathway. The gene discussed is SMAD3; the disease is Hepatic fibrosis.