CD274 and neoplasm: All these interesting results indicate that although TME-modulating treatment with H-MnO2-PEG/C&D could reverse the immunosuppressive microenvironment inside tumors and trigger CTL-mediated anti-tumor immunities, the PD-L1 blockade could further potentiate the generation of tumor antigen-specific CTL effector cells, which are then migrated into the distant tumors to kill tumor cells there.