In such comprehensive treatment strategy, the tumor-killing CTL effector cells generated after the chemo-PDT treatment plus PD-L1 blockade would migrate into other distant tumors and destruct those tumor cells expressing the same type of tumor-associated antigens, promising for effectively killing of tumor cells that cannot be directly irradiated by light during PDT, as well as for tumor metastasis inhibition. The gene discussed is CD274; the disease is neoplasm.