CD274 and neoplasm: As expected, H-MnO2-PEG/C&D-based chemo-PDT treatment showed further improved therapeutic efficacy in combating the primary tumor progression (the left tumor with light exposure) when combining with PD-L1 blockade, in comparison to chemo-PDT alone with H-MnO2-PEG/C&D (Fig. 7b, c).