CD274 and neoplasm: In marked contrast, the CTL infiltration levels within distant tumors in other control groups, including chemo-PDT with H-MnO2-PEG/C&D (no PD-L1 blockade) and H-MnO2-PEG/C&D injection plus anti-PD-L1 (no light irradiation on the primary tumor), were not significantly affected (Fig. 7f; Supplementary Fig. 11).