Therefore, such chemo-PDT treatment with H-MnO2-PEG/C&D in combination with PD-L1 blockade could not only effectively kill primary tumor cells with direct light exposure, but also inhibit the growth of distant tumors (e.g., tumors located deeply inside the body, or too small to be detected before treatment) spared from light exposure. This evidence concerns the gene CD274 and neoplasm.