PPARA and rheumatoid arthritis: In a recent study inmice, C18:2 c9, t11 (RA) reduced arthritis severity equivalently tocelecoxib, through a reduction in IL-6 and interleukin 1 β(IL-1β), thus suggesting that dietary RA may be an effectivecyclooxygenase (COX2) inhibitor [76].The second proposed mechanism places CLA as an agonist of all PPAR isoforms[77], proteins involved inadipocyte differentiation/proliferation, glucose uptake, mitochondrialfunction and inflammation [78].