CDK4 and skin carcinoma: Moreover, mixtures of C4, C6, C8and C10 down-regulated genes involved in cycle division and progression ofhuman cell lines of colorectal (cyclin-dependent kinase 2 (CDK2);cyclin-dependent kinase 4 (CDK4); CDC 28 protein kinase 1B (CKSIb); cyclinA2 (CCNA2) and cyclin D (CCND1)) and skin carcinoma (CKSIb, CCNA2 and CCND1)and mammary gland adenocarcinoma (CDK4, CKSIb, CCNA2 and CCND1) and, ingeneral, lower the chain length lesser the efficiency [111].