Moreover, cancer cells can also rely on acetate uptake from three different sources:foods (e.g. meat, cheese, pickles), intestinal microbiota (fibre fermentation,besides resulting in short-chain fatty acid (SCFA), propionate and butyrate) andliver (while fasting, acyl­CoA thioesterase 12 (ACOT12) is activated andhydrolyses acetyl-­CoA) [4]. This evidence concerns the gene ACOT12 and cancer.