Thus, adding elaidic acid (C18:1t9; the main industrial trans fat) to umbilical veinendothelial cells (HUVEC) and human hepatocellular carcinoma (HepG2) cellsincreased SDC, while TVA reduced the tumour necrosis factor-α(TNF-α) induced gene expression of TNF, VCAM-1 andSOD2 in HUVEC and IL-8 in HepG2 cells[89]. This evidence concerns the gene TNF and hepatocellular carcinoma.