Consistently, Wang et al. [6] found that the down-regulation of FAP in oral cancer could inhibit cell propagation by activating phosphatase and tensin homology deleted on chromosome 10/phosphoinositide 3-kinase/AKT (PTEN/P13K/AKT) and Ras-extracellular signal regulated kinase (Ras-ERK) signaling pathways. This evidence concerns the gene AKT1 and lip and oral cavity carcinoma.