AKT1 and neoplasm: Some studies indicate that ROS levels significantly increased in tumor cells and plays a vital role in the occurrence and development of tumors and also participates in many signaling pathways, such as mitochondrial mediated caspase-dependent apoptotic pathway [36] and regulation of Akt/MAPK-related signaling pathways [37], and even affect the proliferation and differentiation of tumor cells [38–40].