AKT1 and hepatocellular carcinoma: Misexpression of the TRIB3 R84 variant in human hepatoma cell lines blocks AKT phosphorylation at Ser473 more effectively than the Q variant, leading to the notion that the R variant is a more potent inhibitor of AKT activation, and, consistent with this, the R variant physically binds AKT more strongly than the Q variant (Andreozzi et al., 2008; Gong et al., 2009; Prudente et al., 2005, 2010).