We reported previously that fly Trbl has a conserved role in modulating Akt to regulate the insulin signaling pathway (Das et al., 2014) and, here, we extend these data by demonstrating that a conserved site in Trbl corresponding to an SNP variant R84 in human TRIB3, which is associated with insulin resistance, is important in the modulation of insulin signaling in flies as well (Prudente et al., 2005). The gene discussed is INS; the disease is Insulin resistance.