A prevalent single nucleotide polymorphism (dsSNP ID: rs2295490) in the human TRIB3 coding sequence predisposes carriers to early onset insulin resistance and early onset Type 2 diabetes (Andreozzi et al., 2008; De Cosmo et al., 2007; Formoso et al., 2011; Gong et al., 2009; Prudente et al., 2005, 2010, 2013; Shi et al., 2009; Zhang et al., 2015; reviewed in Hegedus et al., 2006; Prudente et al., 2015). Here, TRIB3 is linked to type 2 diabetes mellitus.