KLK3 and Familial prostate cancer: Inclusion criteria:Men at least 18 years of age referred with clinical suspicion of prostate cancer who have been advised to have a prostate biopsySerum PSA ≤20 ng/mL within the previous 3 monthsSuspected stage ≤T2 on rectal examination (organ-confined prostate cancer) within the previous 3 monthsFit to undergo all procedures listed in the protocolAble to provide written informed consent