CD274 and neoplasm: Our sub-analysis indicated that the ratios of cytotoxic T cells to regulatory T cells (CD8+T:Foxp3) and cytotoxic T cells to PD-L1 (CD8+T:PD-L1) tended to predict anti-tumor interactions in the microenvironment, indicating that the combination of CD8+T, Foxp3 and PD-L1 exhibits more predictive potential than PD-L1 expression or CD8+ TIL density alone.