NPPB and type 2 diabetes mellitus: Finally, the recent article by Januzzi et al. [17] demonstrated that chronic therapy with Canagliflozin is associated with delayed physiologic rise in serum NT-proBNP and high sensitive troponin I (hsTnI) in a 2 years’-follow up in older T2D patients by a little but significative amount, thus suggesting a beneficial role.