SLC5A2 and type 2 diabetes mellitus: To date, no data on the effect of SGLT2 inhibitors on cardiac remodeling in subjects with HF is available, but the REFORM trial [66] is currently underway in order to investigate, in patients with T2D and HF, the effects of dapagliflozin on LV remodeling through cardiac magnetic resonance and cardiopulmonary stress test.