The study provides the strongest evidence to date that P. falciparum, via PfEMP1, is involved in the pathogenesis of both RP and RN/PfHRP-2-low CM, and thus provides further support for PfEMP1, and in particular EPCR-binding PfEMP1, as a target for interventions to prevent severe malaria. The gene discussed is PROCR; the disease is malaria.