In the present study, we show that children with severe malaria have higher levels of both EPCR-binding group A and DC8 PfEMP1 transcripts than children with asymptomatic parasitemia, that transcript levels of EPCR-binding PfEMP1 are higher in children with CM than SMA, that children with both CM and SMA have higher levels of EPCR-binding group A PfEMP1 transcripts than children with CM alone, and that PfEMP1 transcript levels in RN or PfHRP-2-low CM fall between those in RP CM and those in SMA. Here, PROCR is linked to malaria.