PROCR and malaria: Specifically, group A and DC8 PfEMP1 that bind EPCR have been suggested to play a key role in severe malaria, through their ability to support IE binding to various microvasculature beds [33, 34] and through reducing the production and cytoprotective effects of activated protein C, due to functional impairment of EPCR upon PfEMP1 engagement [35–37].