The findings regarding EPCR-binding PfEMP1 expression are largely consistent with conclusions drawn from two recent studies in Tanzania, showing that CIDRα1 was the only common domain encoded by most prominently expressed var transcripts in CM and SMA patients [43], and that higher levels of EPCR-binding PfEMP1 transcripts were associated with increasing symptoms of severity in patients suffering uncomplicated malaria vs. SMA or CM [32]. Here, PROCR is linked to malaria.