Moreover, alterations in glypicans (Calboli et al., 2010, Doan et al., 2016, Lesch et al., 2008, Pinto et al., 2010, Potkin et al., 2010) and RPTPδ (Choucair et al., 2015, Elia et al., 2010, Pinto et al., 2010) have been linked to the pathophysiology of disorders, including ASD, schizophrenia, ADHD, and neuroticism, and more recently, neuronal pentraxins have been linked to cognitive dysfunction in Alzheimer’s disease (Xiao et al., 2017). Here, GPC1 is linked to Alzheimer disease.