Recent data from our group showed that TG synthesis is an important pathway in the development of age‐related hepatic steatosis and in patients with NAFLD and that a critical regulator of this pathway is the p300‐C/EBPα/β complex that binds and activates the promoters for several enzymes in the TG synthesis pathway, including DGAT1 (Jin et al., 2013, 2016). Here, EP300 is linked to metabolic dysfunction-associated steatotic liver disease.