CAFs have been shown to stimulate cancer progression and proliferation through helping create the extracellular matrix (ECM) and through the secretion of a variety of cytokines, chemokines, and growth factors, such as vascular endothelial growth factor (VEGF), transforming growth factor‐β (TGF‐β), and fibroblast growth factor 2 (FGF2) (Kalluri, 2016; Kalluri and Zeisberg, 2006; Orimo et al., 2005; Shen et al., 2016). This evidence concerns the gene FGF2 and cancer.