When stratified by obesity status and PA level, carriers of the following SNPs had decreased risk of CRC in non-obese women: AKT2 rs11673367 A allele (in waist ≤ 88, w/h ≤ 0.85, and MET ≥ 10 groups); AKT2 rs3730256 T allele (in BMI < 30 and w/h ≤ 0.85 groups); AKT2 rs7247515 A allele (in w/h ≤ 0.85 group); AKT2 rs4332845 A allele (in MET ≥ 10 group); and AKT1 rs1130214 T allele (in w/h ≤ 0.85 group). Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.