Differently, carriers of one SNP (rs2304186 A allele) in the AKT2 gene in the obese (BMI ≥ 30) group had increased risk of CRC, and about 50% of the CRC risk due to this SNP was explained by IGFBP3 levels (Tables 4 and 5). This evidence concerns the gene IGFBP3 and colorectal carcinoma.