When participants were classified by exogenous E use status, 4 SNPs in nonusers were associated with CRC risk (Table 2): the IGF-I rs10778176 T allele, with increased risk, and the IGFBP3 rs2471551 C and rs3110697 A alleles and the INS rs3842763 A allele, with decreased risk. Here, IGFBP3 is linked to colorectal carcinoma.