Among the 33 IGF/IR-related SNPs we evaluated, 6 (of the 19 IGF-IR traits) in the INS, IGF-I, and IGFBP3 genes and 11 (of the 14 IGF/IR signaling pathway) in the IRS1 and AKT1/2 genes were associated with CRC risk. The gene discussed is IRS1; the disease is colorectal carcinoma.