The IGF-I/insulin resistance (IR) axis has been associated with CRC in multiple studies.[3–5] Higher levels of total/ free bioactive IGF-I and lower levels of IGF-binding protein 3 (IGFBP3) have been associated with higher CRC risk in both pre- and post-menopausal women.[3, 4, 6]. This evidence concerns the gene IGFBP3 and colorectal carcinoma.