Further, when stratified by exogenous E use, carriers of the AKT1 rs2494738 T and rs2498789 C alleles had an increased risk of CRC among nonusers; however, in E+P users, carriers of the rs2494738 T allele had a reduced risk of CRC (with 30% of the SNP–cancer association explained by insulin level). Here, AKT1 is linked to colorectal carcinoma.