For each SNP with mediators, the IGF-I/IR trait SNP–CRC association was evaluated by stratification via obesity status (BMI < 30 kg/m2 vs. ≥ 30 kg/m2; waist ≤ 88 cm vs. > 88 cm; and w/h ≤ 0.85 vs. > 0.85), level of PA (metabolic equivalent [MET hours·week-1] ≥ 10 vs. < 10) (Table 1), and by exogenous E use (nonuse vs. E-only or E+P use) (Table 2). Here, IGF1 is linked to obesity due to melanocortin 4 receptor deficiency.