IRS1 and Insulin resistance: Genetic alteration in the relevant gene is associated with impaired downstream signaling, leading to insulin resistance and probably cancer.[22] Several previous studies evaluated the association between the IRS1 rs1801278 (Gly972Arg) and CRC risk and showed inconsistent findings: no significant relationship [13, 18], increased risk [11, 17], and decreased risk [10] of CRC with the T allele (vs. the C allele) in this SNP were examined.