Laine et al. reported a high frequency of the same IL-1A and/or IL-1B gene polymorphisms as in the present study in adults with periodontitis, although they selected the VNTR for the IL-1RN gene for investigation and did not detect P. gingivalis or A. actinomycetemcomitans by culture techniques [40]. The gene discussed is IL1B; the disease is periodontitis.