It is also reminiscent of the aberrant aggregation-dependent cytosolic migration seen for nuclear RNA-binding proteins with LCDs such as TDP-43, fused in sarcoma (FUS), or hnRNP-A1 which aberrantly accumulate in the cytosol in diseases such as amyotrophic lateral sclerosis [17]. Here, FUS is linked to amyotrophic lateral sclerosis.