For instance, one of our highly ranked nodes, NFKB2 (S1 Fig), a subunit of the NFKB transcription factor, has been previously found to be up-regulated in a dose-dependent fashion by gemcitabine, and its inhibition reduced gemcitabine resistance robustly across pancreatic cancer cell lines BxPC3, Capan1 and PancTu1 [37]. The gene discussed is NFKB1; the disease is familial pancreatic carcinoma.