SHC1 and familial pancreatic carcinoma: Of these targets supported by literature to be involved in pancreatic cancer, 9/14 were previously implicated in gemcitabine resistance: NFKB2, AKT1, ZEB1, NFATC2, SHC1 and MUC1 modify gemcitabine resistance in pancreatic cancer, while ELK1 increases gemcitabine cytotoxicity in prostate cancer but has also been studied due to its transcription regulatory effect in pancreatic cancer.