CHEK1 and familial pancreatic carcinoma: The three genes that were revealed in both screens were WEE1, a tyrosine kinase that has previously been found to synergize with gemcitabine in a subset of pancreatic cancer xenografts [23], CHEK1, a key-regulator of cell-cycle that has been implicated in gemcitabine resistance in some pancreatic cell lines [24] and AURKA, a kinase involved in mitotic spindle function.