ZEB1 and familial pancreatic carcinoma: Similarly, ZEB1 (Fig 4C), a protein involved in the epithelial to mesenchymal transition already has an established role in gemcitabine resistance: its levels are inversely correlated with cellular response to gemcitabine, and silencing ZEB1 increases gemcitabine-induced apoptosis in pancreatic cancer cell lines PANC1, HS766T and Miapaca2 [34].