NOTCH1-dependent T-ALL cell lines (e.g., CUTLL1, DND-41, and KOPT-K1) have RBPJ/Notch binding sites 1.3 Mb 3’ of the MYC gene body that are associated with a broad multidomain enhancer defined by H3K27 acetylation marks and binding of the BET bromdomain protein BRD4 [23, 28]. Here, RBPJ is linked to acute lymphoblastic leukemia.