The enrichment for RUNX motifs near functional RBPJ/NOTCH1 sites also has been reported in T-ALL cells [16] and likely serves as a mechanism to integrate RUNX and Notch inputs during blood and immune cell differentiation, in line with prior reports of functional interactions between Runx factors and Notch in fish [17], flies [18], and mice [19]. The gene discussed is RBPJ; the disease is acute lymphoblastic leukemia.