NOTCH3 and acute lymphoblastic leukemia: Notably, in contrast to other T-ALL cell lines such as CUTLL1, which have high levels of H3K27ac in both the NDME and the BDME, in TALL1 cells the H3K27ac signal in this region is attenuated by comparison, and most of the H3K27ac marks that are present are confined to the region near a dynamic NOTCH3 binding site in the NDME (Fig 6).