NOTCH1 and acute lymphoblastic leukemia: In prior studies of NOTCH1-dependent T-ALL cells, MYC expression has been linked to a large 3’ enhancer region denoted by a high content of acetylated H3K27 that contains a Notch-dependent MYC enhancer (NDME) module and a more 3’ BRD4-dependent MYC enhancer (BDME) module [22, 23].