STAT3 and neoplasm: In addition, many TFs have been recently elucidated as Master Regulators of tumor cell state, which are organized in highly interconnected modules or tumor checkpoints [8], including key synthetic lethal combinations, such as STAT3, CEBPB, and CEBPD in mesenchymal glioblastoma [9] or CENPF and FOXM1 in malignant prostate carcinoma [10].