The specific highest IRS in MCF7 (breast cancer, BRCA), HL60 (acute promyelocytic leukemia, APL), and PC3 (prostate cancer, PRAD) cells was achieved by fulvestrant (ESR1 antagonist), tretinoin (all-trans retinoic acid), and pioglitazone, respectively. This evidence concerns the gene IARS1 and Familial prostate cancer.