Hence, 3T3-L1 adipocytes lose their sensitivity to insulin in vitro when exposed to H2O2 even in micromolar concentration range [110]; while insulin resistance in this cells induced by TNF-α could be reversed by boosting antioxidant defenses [111] (e.g., β-carotene accumulation) suggesting the link between oxidative stress and insulin resistance. The gene discussed is TNF; the disease is Insulin resistance.