Interestingly, anthocyanin (e.g., cyanidin-3-O-glucoside) have been shown to downregulate the RBP4 in the white adipose tissue in type 2 diabetic mice while at the same time upregulating the GLUT-4 and suppressed adipocytokines (monocyte chemoattractant protein-1 and tumor necrosis factor-α) [86]. This evidence concerns the gene TNF and type 2 diabetes mellitus.