CD22 and lymphoma: Numerous ITs formed by a toxic RIP domain like saporin, PAP, momordin and RTA, combined with a monoclonal antibody against markers of hematological malignancies such as CD2, CD19, CD22, CD25, CD30, CD38 and CD123 have been tested alone or in combination in animal models of lymphoma and leukemia [97,98,99,100,101,102] and some underwent early clinical phase studies.