In this context, when analyzing the effects of a targeted toxin, also the choice of the targeting moiety itself may also implicate different/alternate modalities in cell killing capabilities of the IT, as demonstrated by some studies by the group of Bolognesi: they compared cytotoxicities of two immunotoxins one obtained (by chemical conjugation of the plant toxin) conjugating seed saporin to Rituximab, an α-CD20 chimeric humanized antibody already approved by the United States (U.S.)Federal Drug Administration (FDA) to treat lymphomas, and the other one to OM124 an α-CD22 murine antibody. This evidence concerns the gene CD22 and lymphoma.