In the field of ligand-targeted chimerae, toxins have been in particular fused or conjugated to growth factors (EGF, [103], FGF [104] and VEGF [105]), but also with other polypeptides, such as uPa [106] and NCAM [107] as well, whose receptors have been found over-expressed on the cell surface of different cancer cells or in tumor vasculature, allowing to test the same therapeutics on several tumor models. Here, VEGFA is linked to neoplasm.