In the field of ligand-targeted chimerae, toxins have been in particular fused or conjugated to growth factors (EGF, [103], FGF [104] and VEGF [105]), but also with other polypeptides, such as uPa [106] and NCAM [107] as well, whose receptors have been found over-expressed on the cell surface of different cancer cells or in tumor vasculature, allowing to test the same therapeutics on several tumor models. This evidence concerns the gene EGF and neoplasm.