Obesity is also associated with elevated levels of proinflammatory cytokines in the circulation and in tissues [21], and thus, we found that IL-1β, IL-4, and TNF-α levels in the serum were increased in the HFD group, and all of the three supplements sufficiently reduced these levels (Figure 4B–D). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.