Obesity is also associated with elevated levels of proinflammatory cytokines in the circulation and in tissues [21], and thus, we found that IL-1β, IL-4, and TNF-α levels in the serum were increased in the HFD group, and all of the three supplements sufficiently reduced these levels (Figure 4B–D). The gene discussed is IL4; the disease is obesity due to melanocortin 4 receptor deficiency.