At the time of enrolment, five of the 15 drug-naïve RA patients (14 Caucasians and one Chinese; 12 females; mean age 54.8 ± 16.2 years; mean disease duration 2.3 ± 3.9 years) had ACPAs, seven had rheumatoid factor (RF), and two had anti-nuclear antibodies (ANAs); their mean C-reactive protein/28-joint disease activity score (CRP-DAS28) was 4.6 ± 1.0. This evidence concerns the gene CRP and glycogen storage disease VI.