CYP4F3 and type 2 diabetes mellitus: Moreover, as seen with CYP4A, Figure 4 (lower panel) shows a significant increase in relative expression of CYP4F proteins that was observed in the liver of T2D mice when compared to the control animals (2.53 ± 0.22 vs. 1.10 ± 0.07; p < 0.001).