CYP2C18 and type 2 diabetes mellitus: Figure 2 (lower panel) also shows a significant reduction in relative expression of CYP2C proteins that was observed in the liver of T2D mice when compared to the control animals (1.56 ± 0.17 vs. 2.21 ± 0.19; p < 0.01). Upper panel shows the representative blot images of hepatic CYP2C and the total proteins loaded for both the control and T2D groups. In contrast, Figure 3 (lower panel) shows a significant increase in relative expression of CYP4A proteins that was observed in the liver of T2D mice when compared to the control animals (1.06 ± 0.09 vs. 0.18 ± 0.01; p < 0.001).