On the other hand, CHK2 can also promote p21 accumulation, which leads to G2/M arrest.33 Our results suggest that DCZ3301 induces DNA damage by inhibiting CDK1–cyclinB1 kinase activity through both p21 and cdc25A/cdc25C pathways in DLBCL. Here, CDK1 is linked to diffuse large B-cell lymphoma.