As shown in Figure 3d, treatment of OCI-LY8 and NU-DUL-1 cells (8 or 16 μM) with DCZ3301 caused dose-dependent increase in the cleaved forms of caspase-3, caspase-8 and caspase-9 as well as PARP, indicating that DCZ3301 induces apoptosis in DLBCL cells through both extrinsic and intrinsic pathways. This evidence concerns the gene CASP8 and diffuse large B-cell lymphoma.