TP53 and colorectal carcinoma: In the present study, we revealed that p53 promoted miR-124 expression to inhibit iASPP expression, so as to amplify the inhibitory effect of PDT on CRC cell proliferation; after p53 mutantion or knockout, miR-124 expression was downregulated while iASPP expression was upregulated, so that the inhibitory effect of PDT on CRC cell proliferation was reduced (Figure 7).