Inhibitor of apoptosis-stimulating protein of p53 (iASPP), the oncoprotein inhibitory member of the ASPP family, could be inhibited so as to affect the CRC cell proliferation according to our previous study.14 In certain malignant cells, p53 mutation may trigger the activation of gain of function (GOF), bringing up the expression of some carcinogenic factors while knocking down other tumor suppressors.15 Some of these are transcriptional regulators of great importance in regulating tumor growth and cell apoptosis, such as miR-124. The gene discussed is PPP1R13L; the disease is colorectal carcinoma.