According to previous studies, iASPP is a key inhibitor of the tumor-suppressor p53 in various cancers, including prostate cancer,37 liver cancer,38 lung cancer39 and glioma.40 Dong et al.41 summarize the oncogenic roles of iASPP in promoting proliferation, invasion, drug or radiation resistance and metastasis. Here, TP53 is linked to central nervous system cancer.