The p53 gene mutation is 0% (0/25), 44.8%(1 (/38), 43.6% (34/78) and 42.1% (8/19), respectively, in normal mucosa tissue, colorectal adenomas, single lesion and multiple lesion of primary colorectal carcinomas,11 indicating that the mutation of p53-suppressor gene has a significant role in the procedure of colorectal tumorigenesis. The gene discussed is TP53; the disease is colorectal carcinoma.