For the first time, we demonstrated the amplificatory effect of miR-124 on PDT suppressing CRC cell viability, which could be partially abolished by p53 mutation or deletion; on the contrary, iASPP suppressed the inhibitory effect of PDT on CRC cell viability, which could be amplified by p53 mutation or deletion. The gene discussed is PPP1R13L; the disease is colorectal carcinoma.