VEGFA and neoplasm: The pattern of miRNA expression varies dramatically across tumor types, and miRNA profiles reflect the developmental lineage and differentiation state of a tumor.42 miRNA is also likely to have critical roles in the PDT process.43 Hypoxia induced by PDT induces miR-210 expression, followed by an increased expression of both VEGF and miR-296.44 Bach et al.45 identified eight miRNAs that were significantly differentially expressed 5 h after PDT, compared with baseline levels, and an up to 15-fold transient upregulation of miR-634, -1246 and -1290 relative to their basal levels.