Interestingly, many recent studies have focused on understanding Tnmd involvement in obesity and diabetes.46, 47, 48, 49, 50, 51, 52 Of interest, Senol-Cosar et al.46 suggested that Tnmd facilitates pre-adipocyte terminal differentiation while Jiang et al.14 showed that overexpression of Tnmd actually inhibits adipogenesis of murine MSCs. This evidence concerns the gene TNMD and obesity due to melanocortin 4 receptor deficiency.