Since we found that Lnc-Myd88 could promote HCC cells growth and metastasis in vitro and in vivo and regulated the expression of Myd88 in transcription level through adjusting the enrichment of the H3K27ac of the promoter of Myd88, we wondered whether NF-κB and PI3K/AKT signal pathways were involved in the mechanism of carcinogenic function of Lnc-Myd88. The gene discussed is MYD88; the disease is hepatocellular carcinoma.