Emerging information on the molecular mechanisms of CDK14 also indicates that CDK14 mediates the phosphorylation of cell cycle-dependent low-density LRP6, thereby promoting Wnt signalling.62, 65 In addition, knockdown of CDK14 inhibited the expression of PI3K and Akt phosphorylation in pancreatic cancer cells.47 In this study, we demonstrated that miR-216a/CDK14 axis also regulated the phosphorylation of LRP6 and the expression of other downstream genes in Wnt signalling in OS cells. Here, LRP6 is linked to familial pancreatic carcinoma.