In colorectal cancer, miR-216a suppresses tumour metastasis an invasion through downregulation of KIAA1199/CEMIP.55 Besides, miR-216a decreases MALAT1 and JAK2 expression in pancreatic cancer cells.56, 57, 58 In addition, miR-216a also exerts its function as a tumour suppressor in prostate cancer, lung cancer and liver cancer.58, 59, 60 Moreover, for oral squamous cell carcinoma, miR-216a inhibits the growth and metastasis by targeting eukaryotic translation initiation factor 4B.61 However, investigations on the tumour suppressive role of miR-216a in OS are still lacking. Here, JAK2 is linked to Familial prostate cancer.