miR-544a induces the EMT by activating the WNT signaling pathway.42 We previously found that miR-7 suppresses the EMT and GC metastasis by targeting IGF1R.43 In this study, we explored how miR-143 and miR-145 regulate the EMT in GC and found that the overexpression of miR-143 and/or miR-145 inhibited the EMT in GC cells, with a corresponding increase in E-cadherin and β-catenin levels and a decrease in vimentin expression. This evidence concerns the gene IGF1R and gastric cancer.