For instance, miR-203 targets ZEB2 and RUNX2 to suppress the EMT and bone metastasis of prostate cancer cells.10 miR-483-5p exerts pro-EMT and pro-metastatic functions by regulating RhoGDI1 and ALCAM in human lung adenocarcinoma.11 In GC, miR-338-3p inhibits EMTs by regulating ZEB2 and MACC1/Met/Akt signaling. This evidence concerns the gene RUNX2 and Familial prostate cancer.