ALCAM and cancer: For example, miR-203 suppresses the bone metastasis of prostate cancer via the inhibition of the pro-EMT gene ZEB2,10 and miR-483-5p promotes the EMT in conjunction with an increase in the invasive and metastatic properties of lung adenocarcinoma by targeting RhoGDI1 and ALCAM.11 However, in GC, the second most common type of cancer in Asia in terms of incidence and cancer mortality, the roles of miRNAs, especially EMT-regulated miRNAs, remain to be elucidated.