FOXO4 and neoplasm: For example, the miR-200 family promotes metastatic colonization by directly targeting ZEB1 and ZEB2 in ovarian cancer.7 miRNA-362-5p promotes tumor metastasis by targeting CYLD in hepatocellular carcinoma,8 and miR-150 promotes metastasis in non-small cell lung cancer by targeting FOXO4.9 In particular, miRNAs can modulate tumor metastasis by regulating the EMT.