Moreover, previous study demonstrated that HCC cell invasion could be suppressed via altering the AR-FKBP5-PHLPP-(pAKT and pERK) signals.17 Here in the present study, FKBP5 and PHLPP were decreased and pAKT (S473) and pERK (Thr202/Tyr204) were hence increased by sorafenib treatment. Here, PHLPP1 is linked to hepatocellular carcinoma.