ABL1 and Parkinson disease: c-Abl has been implicated in the pathogenesis of neurodegeneration, in which mitochondria are usually dysregulated.29 The neurotoxin MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) has been widely used to establish the murine model of PD.30 To explore the role of c-Abl in mitochondrial dynamics, c-Ablflox/flox mice were crossed with CamKIIα-iCre transgenic mice to generate the mice with c-Abl deletion in neurons.