However, miR-34a deficiency strongly promotes tumorigenesis when p53 is haploinsufficient, suggesting that the defective p53-miR-34 feedback loop can enhance oncogenesis in a specific context.40 Consistently, prostate epithelium-specific inactivation of miR-34 and p53 leads to expansion of the prostate stem cell compartment and development of early invasive adenocarcinomas and high-grade prostatic intraepithelial neoplasia through enhanced MET signaling.55 Here, TP53 is linked to prostate intraepithelial neoplasia.