In the context of senescence, miR-34a was identified as a key mediator of c-Myc and E2F repression, mediating indirect downregulation of an entire set of mitotic genes and telomerase activity.6, 96, 97 B-RAF-induced senescence of human fibroblasts was accompanied by p53-independent induction of miR-34a, mediated by an ETS-family transcription factor ELK-1.96 ELK-1 was described as a miR-34a regulator also in a feedback regulation of tyrosine kinase AXL, implicated in cancer invasion, EMT and chemoresistance. This evidence concerns the gene MYC and cancer.