While computational analysis of microarray data proposes a positive correlation between miR-34a expression and TGF-β signaling,50 TGF-β inhibited miR-34a expression in hepatocellular carcinoma and through miR-34a-CCL22-Treg axis promoted tumor progression and immune escape in p53-deficient cells.86 Contrarily, miR-34a induction by TGF-β silencing was associated with p53 induction and activation in HeLa cells.99 This evidence concerns the gene TGFB1 and hepatocellular carcinoma.