WAS and chronic myelogenous leukemia, BCR-ABL1 positive: Interestingly, when the OS was calculated just for CML patients in advanced phases, resistant to TKIs and with significantly lower levels of WASP compared with healthy donors, we observed that milder suppression of WASP (levels above median – WASP low) correlated with longer OS, whereas strong suppression of this gene (levels below median – WASP very low) correlated with poorer OS (Figure 4b).