Specifically, both the BrM and RPE basal in-foldings were thicker, which were similar to the ultrastructural alterations in APOE4-HFC-induced AMD models, in which the expression of Aβ1-40/42 elevated.18 To test whether or not visual function was impaired by Aβ peptide, electroretinogram (ERG) was performed at day 4 since the injection. Here, APOE is linked to age-related macular degeneration.