MYC and leukemia: MYC activation is frequent because of chromosomal translocations and transcriptional amplification in hematopoietic malignancies such as leukemia and lymphoma.25, 26 However, the role of MYCN has been poorly understood due to tissue restriction.27 Overexpression of MYCN was observed in adult leukemia patients from some studies with a small sample size.14, 15 Kawagoe et al.15 reported that overexpression of MYCN not MYC rapidly causes AML in mouse model, which emphases the driving effect of MYCN on leukomogenesis.