Previous study revealed that MLN8237 induces cell apoptosis and senescence and inhibits cell proliferation through the upregulation of p21 and p27 expression in multiple myeloma.43 MLN8237 also impaired mitosis, induced senescence and markedly blocked proliferation in metastatic melanoma tumors.44 These results suggested a potential treatment possibility of MLN8237 for erythroleukemia. Here, CDKN1A is linked to erythroleukemia.