Our results showed that ATG7 downregulation could also induce ovarian cancer cell proliferation, reduce apoptosis by reducing LC3-II and LAMP1 expression, and induce SQSTM1 expression; furthermore, ATG7 co-transfection with HULC partly reversed the function of HULC in tumorigenesis both in vitro and in vivo. The gene discussed is HULC; the disease is ovarian cancer.