Similarly, Michels et al. characterized three proinsulin-reactive T cell clones (i.e., 20D11, 6H9, and 8E3) isolated from human T1D islets; 20D11 and EH9 are the first human intra-pancreatic isolates specific for the insulin B:9–23 peptide [168••]. This evidence concerns the gene INS and type 1 diabetes mellitus.