We previously reported that RAMP2 is the key modulator of the endogenous vasoprotective peptide adrenomedullin (Ichikawa-Shindo et al., 2008), and that vascular endothelial cell-specific RAMP2 knockout mice show vascular inflammation and liver fibrosis (Koyama et al., 2013). Here, ADM is linked to Hepatic fibrosis.