Although the MCD diet model well replicates the histological features of the fibrosis observed in human NASH, its metabolic context differs from human NASH, as animals fed the MCD diet for prolonged periods lose body weight, show low blood glucose, low blood triglyceride (TG) and cholesterol, unchanged or increased serum adiponectin levels, and elevated peripheral insulin sensitivity, which is a metabolic profile opposite to the human disease (Larter et al., 2008). Here, INS is linked to metabolic dysfunction-associated steatohepatitis.