They also reported that patients with insufficient levels of 25(OH)D3 showed significant inhibitory effects on bone metabolism when treated with 25(OH)D3 in the case of ALN treatment.18 Our previous study showed that IBN addition inhibited bone turnover significantly more in the IBN monotherapy group than in the IBN plus ALF group.15 Vitamin D deficiency generally causes increased serum PTH. The gene discussed is PTH; the disease is vitamin D deficiency.