A reduction of BRCA1 expression can be a result of a deleterious germ-line variant combined with the loss of the wild type allele in the tumour [8] an idiopathic somatic mutation, that lead to mutational inactivation of both alleles [9], or by mechanisms unrelated to the occurrence of a somatic mutation, such as the inhibition of p53 protein, promoter hypermethylation or high NBR2 gene expression [10]. Here, BRCA1 is linked to neoplasm.