The BSSG model is potentially at the center of developments in regulation of liver metabolism (liver XR), Gaucher disease (mutations in the glucocerebrosidase gene (GBA1)), and their role in increased risk for α-synuclein aggregation disorders (“synucleinopathies”), which include PD and dementia with Lewy bodies (DLB). The gene discussed is GBA1; the disease is Gaucher disease.