SNCA and Parkinson disease: While classic neurotoxin models, such as 6-OHDA and MPTP, mimic many of the biochemical features of PD, including reduced levels of striatal dopamine and tyrosine hydroxylase, they typically fail to replicate the accumulation of misfolded α-synuclein, the main component of Lewy bodies and Lewy neurites, another cardinal pathological feature of PD [12, 13].