INS and diabetes mellitus: A 5.4-year prospective cohort study among 1292 Chinese (73 diabetes cases) in Hong Kong reported an OR of 1.79 (95% CI 1.22–2.64) for the risk of diabetes with per 1 unit increment in log FGF-21 levels, after adjusting for fasting glucose, insulin, TG, HDL-C and hs-CRP [7].