CD8A and neoplasm: Strikingly, blood Tregs isolated from patients affected by head and neck squamous cell carcinoma and stimulated with anti-CD3 mAb and IL-2 exhibit a higher level of CD95L as compared to that present at the surface of Tregs from healthy donors, providing a potential explanation for the elimination of tumor-infiltrating CD8+ effector T-cells in these cancer patients (60).