CD8A and neoplasm: Nonetheless, the role of endothelial CD95L remains controversial because, while Coukos et al. observed that the membrane-bound ligand served as a barrier to prevent CD8 T-cell extravasation (while sparing Treg accumulation in the tumor tissue) (53) (Figure 1), we found that CD95L on the surface of endothelial cells can be cleaved by metalloproteases to create a gradient that is responsible for accumulation of Th17 cells in inflamed organs (extravasation) (10, 36) or the metastatic dissemination of TNBC cells (intravasation) (37) (Figure 1).