Nonetheless, the role of endothelial CD95L remains controversial because, while Coukos et al. observed that the membrane-bound ligand served as a barrier to prevent CD8 T-cell extravasation (while sparing Treg accumulation in the tumor tissue) (53) (Figure 1), we found that CD95L on the surface of endothelial cells can be cleaved by metalloproteases to create a gradient that is responsible for accumulation of Th17 cells in inflamed organs (extravasation) (10, 36) or the metastatic dissemination of TNBC cells (intravasation) (37) (Figure 1). This evidence concerns the gene FASLG and neoplasm.