Adipose-derived exosomes isolated from serum and urine of obese youths with physician-diagnosed asthma showed differential expression of miRNAs (miR-15a-5p, miR-153-3p, and miR-138-5p) which target TGF-β signaling and is associated with poor asthma outcome (228). The gene discussed is TGFB1; the disease is asthma.