Transactive response DNA-binding protein 43 kDa (TDP-43) are typically aggregated and accumulated in the neuronal cytoplasm in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS; Neumann et al., 2006). This evidence concerns the gene TARDBP and frontotemporal dementia.