MAPT and argyrophilic grain disease: In the brain with AD or AGD, tau pathology is initiated in the entorhinal cortex (EC) and follows a stereotypical pattern to progressively propagate to the limbic system and eventually to widespread isocortex regions (Braak and Braak, 1991; Saito et al., 2004; Braak and Del Tredici, 2011).