PRDX6 and Infertility: Because the sperm plasma membrane plays a critical role in sperm-oocyte recognition, adhesion, and fusion with the oolemma for fertilization, we propose that the perturbations of the sperm plasma membrane due to the inhibition of or the lack of PRDX6 lowers the ability of the spermatozoon to recognize and bind to the zona pellucida, leading to infertility.